Disclosed are a perfluoropolyether-modified silane compound, an antifouling coating composition comprising the same, and a film comprising the same. More particularly, the present invention provides a novel perfluoropolyether-modified silane compound of the formula (1) below, an antifouling coating composition comprising the compound and, when coated on the surface of transparent glass or plastic materials, providing superior antifouling property, scratch resistance and durability while maintaining the transparency of the materials, and a film formed by coating the composition and applicable as antireflection film or optical filter of flat panel displays such as lenses, glass windows, liquid crystal displays (LCD), plasma display panels (PDP), organic electro-luminescence (EL) and filed emission displays (FED): wherein n is an integer of 10 to 70; m is an integer of 1 to 3; p and q are independently 2 or 3; R1 is C2-C4 alkyl; R2 and R3 are independently C1-C6 alkyl or phenyl; R4 is C3-C5 alkyl or C3-C6 alkyl ether; R5 is C1-C6 alkyl or phenyl; and X is C1-C3 alkoxy.