Invention Grant
- Patent Title: Methods for predicting psychotropic drugs which elicit weight gain
- Patent Title (中): 预测精神药物的方法，引起体重增加
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Application No.: US12441986Application Date: 2007-09-10
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Publication No.: US08148095B2Publication Date: 2012-04-03
- Inventor: Solomon H. Snyder , Alex Huang , Cory Teuscher , Sangwon Kim
- Applicant: Solomon H. Snyder , Alex Huang , Cory Teuscher , Sangwon Kim
- Applicant Address: US MD Baltimore US VT Burlington
- Assignee: The Johns Hopkins University,The University of Vermont College of Medicine
- Current Assignee: The Johns Hopkins University,The University of Vermont College of Medicine
- Current Assignee Address: US MD Baltimore US VT Burlington
- Agency: Banner & Witcoff, Ltd
- International Application: PCT/US2007/019617 WO 20070910
- International Announcement: WO2008/036175 WO 20080327
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/542 ; G01N33/567 ; G01N33/566
Abstract:
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase (AMPK), an action abolished in mice with deletion of histamine H1 receptors. These findings afford a means of developing better therapeutic agents and provide insight into the hypothalamic regulation of food intake.
Public/Granted literature
- US20090304596A1 Methods for Predicting Psychotropic Drugs Which Elicit Weight Gain Public/Granted day:2009-12-10
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