Invention Grant
US08148102B2 Sequences for FK228 biosynthesis and methods of synthesizing FK228 and FK228 analogs
失效
FK228生物合成的序列和合成FK228和FK228类似物的方法
- Patent Title: Sequences for FK228 biosynthesis and methods of synthesizing FK228 and FK228 analogs
- Patent Title (中): FK228生物合成的序列和合成FK228和FK228类似物的方法
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Application No.: US12526202Application Date: 2008-02-08
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Publication No.: US08148102B2Publication Date: 2012-04-03
- Inventor: Yi-Qiang Cheng
- Applicant: Yi-Qiang Cheng
- Applicant Address: US WI Milwaukee
- Assignee: UWM Research Foundation, Inc.
- Current Assignee: UWM Research Foundation, Inc.
- Current Assignee Address: US WI Milwaukee
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2008/053473 WO 20080208
- International Announcement: WO2008/098199 WO 20080814
- Main IPC: C12P1/00
- IPC: C12P1/00 ; C12P21/02
Abstract:
Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods of making FK228, thailandepsin and analogs of these molecules and methods of using these FK228 analogs. Chromobacterium and Burkholderia gene inactivation mutants are provided. Methods of forming a disulfide bond in a chemical are also disclosed.
Public/Granted literature
- US20100261878A1 SEQUENCES FOR FK228 BIOSYNTHESIS AND METHODS OF SYNTHESIZING FK228 AND FK228 ANALOGS Public/Granted day:2010-10-14
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