Invention Grant
- Patent Title: Regulation of gene expression by protein methylation
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Application No.: US11736504Application Date: 2007-04-17
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Publication No.: US08148124B2Publication Date: 2012-04-03
- Inventor: Michael R. Stallcup , Dagang Chen , Heng Hong , Dana W. Aswad
- Applicant: Michael R. Stallcup , Dagang Chen , Heng Hong , Dana W. Aswad
- Applicant Address: US CA Oakland US CA Los Angeles
- Assignee: The Regents of the University of California,University of Southern California
- Current Assignee: The Regents of the University of California,University of Southern California
- Current Assignee Address: US CA Oakland US CA Los Angeles
- Agency: Foley & Lardner LLP
- Agent Antoinette F. Konski
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N15/54
Abstract:
The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.
Public/Granted literature
- US20080051560A1 Regulation of Gene Expression By Protein Methylation Public/Granted day:2008-02-28
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