Invention Grant
US08148151B2 Differentiation of primate pluripotent cells to hepatocyte-lineage cells
有权
灵长类动物多能细胞分化为肝细胞谱系细胞
- Patent Title: Differentiation of primate pluripotent cells to hepatocyte-lineage cells
- Patent Title (中): 灵长类动物多能细胞分化为肝细胞谱系细胞
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Application No.: US12303104Application Date: 2007-06-01
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Publication No.: US08148151B2Publication Date: 2012-04-03
- Inventor: Debiao Zhao , Anish Sen Majumdar , David C. Hay , Wei Cui
- Applicant: Debiao Zhao , Anish Sen Majumdar , David C. Hay , Wei Cui
- Applicant Address: US CA Menlo Park GB Edinburgh
- Assignee: Geron Corporation,The University Court of the University of Edinburgh
- Current Assignee: Geron Corporation,The University Court of the University of Edinburgh
- Current Assignee Address: US CA Menlo Park GB Edinburgh
- Agency: Law Office of Salvatore Arrigo and Scott Lee, LLP
- International Application: PCT/US2007/012982 WO 20070601
- International Announcement: WO2007/143117 WO 20071213
- Main IPC: C12N15/02
- IPC: C12N15/02 ; C12N5/071
Abstract:
Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cells. In certain embodiments, the population of cells produced by the methods is further enriched for hepatocyte-lineage cells.
Public/Granted literature
- US20100086999A1 DIFFERENTIATION OF PRIMATE PLURIPOTENT CELLS TO HEPATOCYTE-LINEAGE CELLS Public/Granted day:2010-04-08
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