Invention Grant
- Patent Title: Peptide inhibitors of ABL kinases
- Patent Title (中): ABL激酶的肽抑制剂
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Application No.: US12095728Application Date: 2006-11-29
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Publication No.: US08148320B2Publication Date: 2012-04-03
- Inventor: Leszek Kotula , Xiaoling Xiong
- Applicant: Leszek Kotula , Xiaoling Xiong
- Applicant Address: US NY New York
- Assignee: New York Blood Center, Inc.
- Current Assignee: New York Blood Center, Inc.
- Current Assignee Address: US NY New York
- Agency: K&L Gates LLP
- Agent Louis C. Cullman; Michelle Glasky Bergman
- International Application: PCT/US2006/045570 WO 20061129
- International Announcement: WO2007/064647 WO 20070607
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/10 ; C07K7/08 ; C07K14/00 ; A61P35/00
Abstract:
Provided are purified compounds comprising SEQ ID NO:1, where the tyrosine at residue (10) is phosphorylated. Also provided are purified compounds comprising SEQ ID NO:1, where the amino acid sequence of the compound is less than 400 amino acids. Additionally provided are methods of determining whether an agent is a candidate inhibitor of an AbI kinase. Further provided are methods of inhibiting an AbI kinase. Also provided are methods of treating a patient having a condition characterized by a mutant AbI kinase. Additionally provided are methods of treating a patient at risk for a condition characterized by a mutant AbI kinase. Methods of labeling an AbI kinase are also provided. Additionally, methods of isolating an AbI kinase from a tissue are provided.
Public/Granted literature
- US20100184652A1 PEPTIDE INHIBITORS OF ABL KINASES Public/Granted day:2010-07-22
Information query
IPC分类:
