Invention Grant
- Patent Title: Method of treating or inhibiting inflammation by multi-domain amphipathic helical peptides
- Patent Title (中): 通过多结构两亲螺旋肽治疗或抑制炎症的方法
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Application No.: US12766761Application Date: 2010-04-23
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Publication No.: US08148323B2Publication Date: 2012-04-03
- Inventor: Alan T. Remaley , Stephen J. Demosky , John A. Stonik , Marcelo J. A. Amar , Edward B. Neufeld , H. Bryan Brewer , Fairwell Thomas
- Applicant: Alan T. Remaley , Stephen J. Demosky , John A. Stonik , Marcelo J. A. Amar , Edward B. Neufeld , H. Bryan Brewer , Fairwell Thomas
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P3/06 ; A61F13/00
Abstract:
Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
Public/Granted literature
- US20100203099A1 MULTI-DOMAIN AMPHIPATHIC HELICAL PEPTIDES AND METHODS OF THEIR USE Public/Granted day:2010-08-12
Information query
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