Invention Grant
US08148324B2 Chemoenzymatic methods for the synthesis of statins and statin intermediates
有权
用于合成他汀类药物和他汀类药物中间体的化疗酶法
- Patent Title: Chemoenzymatic methods for the synthesis of statins and statin intermediates
- Patent Title (中): 用于合成他汀类药物和他汀类药物中间体的化疗酶法
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Application No.: US12032337Application Date: 2008-02-15
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Publication No.: US08148324B2Publication Date: 2012-04-03
- Inventor: William Greenberg , Mark J. Burk , Alexander Varvak , Kelvin Wong
- Applicant: William Greenberg , Mark J. Burk , Alexander Varvak , Kelvin Wong
- Applicant Address: US CA San Diego
- Assignee: Verenium Corporation
- Current Assignee: Verenium Corporation
- Current Assignee Address: US CA San Diego
- Agency: Verenium Corporation
- Agent Brian W. Siddons; Lynn M. Linkowski
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C12P21/00
Abstract:
The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R—(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
Public/Granted literature
- US20080289056A1 CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES Public/Granted day:2008-11-20
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