Invention Grant
US08148349B2 Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection
有权
用于治疗RNA依赖性RNA病毒感染的核苷环状氨基磷酸酯
- Patent Title: Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection
- Patent Title (中): 用于治疗RNA依赖性RNA病毒感染的核苷环状氨基磷酸酯
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Application No.: US12519038Application Date: 2007-12-14
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Publication No.: US08148349B2Publication Date: 2012-04-03
- Inventor: Malte Meppen , Frank Narjes , Barbara Pacini , Cristina Gardelli , Philippe L. Durette
- Applicant: Malte Meppen , Frank Narjes , Barbara Pacini , Cristina Gardelli , Philippe L. Durette
- Applicant Address: IT Rome US NJ Rahway
- Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti S.P.A.,Merck Sharp & Dohme Corp.
- Current Assignee: Istituto di Ricerche di Biologia Molecolare P. Angeletti S.P.A.,Merck Sharp & Dohme Corp.
- Current Assignee Address: IT Rome US NJ Rahway
- Agent Kenneth R. Walton; Jeffrey P. Bergman; Sheldon O. Heber
- International Application: PCT/US2007/025637 WO 20071214
- International Announcement: WO2008/079206 WO 20080703
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H19/11
Abstract:
The present invention provides nucleoside cyclic phosphoramidates of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection using the compounds of formula (I).
Public/Granted literature
- US20100022468A1 NUCLEOSIDE CYCLIC PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION Public/Granted day:2010-01-28
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