Invention Grant
US08148360B2 Supramolecular metallic complexes exhibiting both DNA binding and photocleavage
有权
显示DNA结合和光切割的超分子金属配合物
- Patent Title: Supramolecular metallic complexes exhibiting both DNA binding and photocleavage
- Patent Title (中): 显示DNA结合和光切割的超分子金属配合物
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Application No.: US11851689Application Date: 2007-09-07
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Publication No.: US08148360B2Publication Date: 2012-04-03
- Inventor: Karen J. Brewer , Brenda Winkel
- Applicant: Karen J. Brewer , Brenda Winkel
- Applicant Address: US VA Blacksburg
- Assignee: Virginia Tech Intellectual Properties, Inc.
- Current Assignee: Virginia Tech Intellectual Properties, Inc.
- Current Assignee Address: US VA Blacksburg
- Agency: Whitham Curtis Christofferson & Cook, PC
- Main IPC: A61K31/555
- IPC: A61K31/555 ; C07F15/00
Abstract:
Supramolecular complexes that target and cleave DNA are provided. The supramolecular complexes include at least one metal-to-ligand charge transfer (MLCT) light absorbing unit, at least one Pt based DNA binding unit, and at least one bridging unit that serves to connect the components. The Pt-based DNA binding unit binds the complex to DNA, and the MLCT unit absorbs light, thereby sensitizing molecular oxygen to produce reactive oxygen species in close proximity to the complex and the bound DNA. The reactive oxygen species cleave the bound DNA.
Public/Granted literature
- US20080113954A1 Supramolecular Metallic Complexes Exhibiting Both DNA Binding and Photocleavage Public/Granted day:2008-05-15
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