Invention Grant
US08148365B2 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use
失效
1,4-二氮杂 - 双环[3.2.2]壬基嘧啶基衍生物及其医疗用途
![1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use](/docs/US/2012-04-03/US08148365B2/abs.jpg.600x600.jpg)
- Patent Title: 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use
- Patent Title (中): 1,4-二氮杂 - 双环[3.2.2]壬基嘧啶基衍生物及其医疗用途
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Application No.: US12299106Application Date: 2007-05-29
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Publication No.: US08148365B2Publication Date: 2012-04-03
- Inventor: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B Timmermann , Steven Charles Loechel
- Applicant: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B Timmermann , Steven Charles Loechel
- Applicant Address: DK Ballerup
- Assignee: Neurosearch A/S
- Current Assignee: Neurosearch A/S
- Current Assignee Address: DK Ballerup
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: DK200600730 20060530
- International Application: PCT/EP2007/055171 WO 20070529
- International Announcement: WO2007/138040 WO 20071206
- Main IPC: A61K31/55
- IPC: A61K31/55 ; C07D223/14
![1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use](/abs-image/US/2012/04/03/US08148365B2/abs.jpg.150x150.jpg)
Abstract:
This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors.Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
Public/Granted literature
- US20090181984A1 NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVE AND ITS MEDICAL USE Public/Granted day:2009-07-16
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