Invention Grant
US08148376B2 3, 4-dihydroquinoxalin-2(1H)-ones for use as stearoyl CoA desaturase inhibitors
失效
3,4-二氢喹喔啉-2（1H） - 酮，用作硬脂酰CoA去饱和酶抑制剂
- Patent Title: 3, 4-dihydroquinoxalin-2(1H)-ones for use as stearoyl CoA desaturase inhibitors
- Patent Title (中): 3,4-二氢喹喔啉-2（1H） - 酮，用作硬脂酰CoA去饱和酶抑制剂
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Application No.: US12767515Application Date: 2010-04-26
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Publication No.: US08148376B2Publication Date: 2012-04-03
- Inventor: Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Alexey Ivanov
- Applicant: Jeffrey Chisholm , Dmitry Koltun , Jeff Zablocki , Eric Parkhill , Andrey Glushkov , Natalya Vasilevich , Timur Zilbershtein , Alexey Ivanov
- Applicant Address: US CA Foster City
- Assignee: Gilead Sciences, Inc.
- Current Assignee: Gilead Sciences, Inc.
- Current Assignee Address: US CA Foster City
- Agent J. Elin Hartrum
- Main IPC: A61K31/495
- IPC: A61K31/495
Abstract:
The present invention discloses 3,4-dihydroquinoxalin-2(1H)-ones for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, oily skin conditions, metabolic syndrome, and the like.
Public/Granted literature
- US20100204238A1 BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR USE AS STEAROYL CoA DESATURASE INHIBITORS Public/Granted day:2010-08-12
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