Invention Grant
- Patent Title: Monocyclic anilide spirolactam CGRP receptor antagonists
- Patent Title (中): 单环酰苯胺己内酰胺CGRP受体拮抗剂
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Application No.: US12530898Application Date: 2008-03-07
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Publication No.: US08148390B2Publication Date: 2012-04-03
- Inventor: Craig A. Stump , Ian M. Bell , Harold G. Selnick
- Applicant: Craig A. Stump , Ian M. Bell , Harold G. Selnick
- Applicant Address: US NJ Rahway
- Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; Gerard M. Devlin
- International Application: PCT/US2008/003078 WO 20080307
- International Announcement: WO2008/112159 WO 20080918
- Main IPC: A61K31/513
- IPC: A61K31/513 ; A61K31/4184 ; A61K31/437 ; A61P25/06 ; C07D403/12 ; C07D471/10 ; C07D491/107 ; C07D471/20
Abstract:
The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Public/Granted literature
- US20100152216A1 MONOCYCLIC ANILIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS Public/Granted day:2010-06-17
Information query
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