Invention Grant
US08148526B1 Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
有权
作为蛋白质脱乙酰酶抑制剂的反酰胺化合物及其使用方法
- Patent Title: Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
- Patent Title (中): 作为蛋白质脱乙酰酶抑制剂的反酰胺化合物及其使用方法
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Application No.: US13310168Application Date: 2011-12-02
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Publication No.: US08148526B1Publication Date: 2012-04-03
- Inventor: John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
- Applicant: John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
- Applicant Address: US MA Boston
- Assignee: Acetylon Pharmaceuticals
- Current Assignee: Acetylon Pharmaceuticals
- Current Assignee Address: US MA Boston
- Agency: Lathrop & Gage LLP
- Agent Brian C. Trinque; Giulio A. DeConti, Jr.
- Main IPC: C07D239/42
- IPC: C07D239/42 ; A61K31/505
Abstract:
The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
Public/Granted literature
- US20120083504A1 Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof Public/Granted day:2012-04-05
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