Invention Grant
US08148530B2 Process for the preparation of 3.7-diazabicyclo[3.3.1] nonane compounds
失效
制备3.7-二氮杂双环[3.3.1]壬烷化合物的方法
![Process for the preparation of 3.7-diazabicyclo[3.3.1] nonane compounds](/docs/US/2012-04-03/US08148530B2/abs.jpg.600x600.jpg)
- Patent Title: Process for the preparation of 3.7-diazabicyclo[3.3.1] nonane compounds
- Patent Title (中): 制备3.7-二氮杂双环[3.3.1]壬烷化合物的方法
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Application No.: US11921884Application Date: 2006-06-10
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Publication No.: US08148530B2Publication Date: 2012-04-03
- Inventor: Michael Wessling , Barbara Duecker , Nicole Nitschke
- Applicant: Michael Wessling , Barbara Duecker , Nicole Nitschke
- Applicant Address: DD Frankfurt
- Assignee: Clariant Produkte (Deutschland) GmbH
- Current Assignee: Clariant Produkte (Deutschland) GmbH
- Current Assignee Address: DD Frankfurt
- Agent Tod A. Waldrop
- Priority: DE102005027619 20050615
- International Application: PCT/EP2006/005582 WO 20060610
- International Announcement: WO2006/133869 WO 20061221
- Main IPC: C07D471/04
- IPC: C07D471/04
![Process for the preparation of 3.7-diazabicyclo[3.3.1] nonane compounds](/abs-image/US/2012/04/03/US08148530B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a process for the preparation of 3,7-diazabicyclo[3.3.1]nonane compounds. According to the invention, in a first step, a dicarboxylic acid ester is reacted with a pyridine aldehyde and a primary amine. The piperidone which forms is reacted in a second stage with formaldehyde and a further primary amine. It is essential to the invention that, in the first reaction stage, a C2-C4-alcohol is used as solvent and, in the second reaction stage, a C3-C4-alcohol is used as solvent.
Public/Granted literature
- US20090234124A1 Polyetheramine production method Public/Granted day:2009-09-17
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