Invention Grant
US08148552B2 Process for the synthesis of anticancer (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin
有权
合成表鬼臼毒素的抗癌（poly）氨基烷基氨基乙酰胺衍生物的方法
- Patent Title: Process for the synthesis of anticancer (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin
- Patent Title (中): 合成表鬼臼毒素的抗癌（poly）氨基烷基氨基乙酰胺衍生物的方法
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Application No.: US12733862Application Date: 2008-09-23
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Publication No.: US08148552B2Publication Date: 2012-04-03
- Inventor: Yves Guminski , Martial Grousseaud , Thierry Imbert
- Applicant: Yves Guminski , Martial Grousseaud , Thierry Imbert
- Applicant Address: FR Boulogne Billancourt
- Assignee: Pierre Fabre Medicament
- Current Assignee: Pierre Fabre Medicament
- Current Assignee Address: FR Boulogne Billancourt
- Agency: Hueschen and Sage
- Priority: FR0706692 20070925
- International Application: PCT/FR2008/051697 WO 20080923
- International Announcement: WO2009/050363 WO 20090423
- Main IPC: C07D307/77
- IPC: C07D307/77
Abstract:
The present invention describes a new process for the preparation of (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin useful for their applications in therapeutics as anticancer agents. This process comprises a step of condensation of a primary-amine-containing reactant, whose amine functions are not protected, with β-chloroacetamido-4′-epipodophyllotoxin in a polar aprotic organic solvent.
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