A circuit for driving an LCD panel and a method thereof is provided. The circuit utilizes a timing controller to receive a plurality of low-voltage differential signals (LVDS) provided by an image inverter, wherein the LVDS have a horizontal synchronize signal. The timing controller, based on the horizontal synchronize signal, undergoes a modulation and transmits a plurality of lamp operation controlling signals to an inverter controlling IC, wherein the frequencies of the lamp operation controlling signals are different from one another, thereby changing the frequency of the lamp operation of the inverter controlling IC used in the LCD panel.