An electro-optic color imaging system includes an optical subsystem, a detector subsystem and a digital image processing subsystem. The system is used to image a color-correlated object. In the optical subsystem, the image surfaces for different color channels of the object are substantially separated. Thus, one color channel may be in focus while others are out of focus. The detector subsystem is located at a fixed image distance from the optical subsystem and captures the different color channel images of the object. The image processing subsystem estimates the image of the object by combining the captured color channel images based at least in part on an a priori estimate of the correlation between the color channels.