A system directs action based on distinguishing audio content received in response to placing an outbound call. The system comprises an audio signal analysis system and an audio content analysis system. The audio signal analysis system directs a portion of an audio signal that comprises audio content to the audio content analysis system. The audio content analysis system: i) receives portions of the audio signal comprising audio content; and ii) directs handling of the outbound call in response to detecting a characteristic of the audio content. The audio content system: i) directs a first handling of the outbound call in response to identifying a first characteristic of the audio content; and ii) directs a second handling of the outbound call in response to identifying a second characteristic of the audio content. The first handling of the outbound call may be directed in response to identifying a characteristic of the audio content associated with recorded content and the second handling of the outbound call is directed in response to identifying a characteristic of the audio content associated with real time spoken audio.