A system automatically synchronizes display of adjacent different medical image sequences of an anatomical portion derived for use in Angiography or another medical procedure. The system includes an imaging system for acquiring first and second sets of data at different stages of a treatment procedure representing corresponding first and second image sequences individually comprising multiple temporally sequential individual images of vessels of a portion of patient anatomy. The sequential individual images encompass introduction of a contrast agent into patient vessels. A display presents the first and second image sequences in substantially adjacent display areas to facilitate user comparison. A contrast agent detector automatically analyzes the first and second image sequences to identify a first image frame in both the first image sequence and the second image sequence indicating presence of a contrast agent. A display processor automatically synchronizes presentation of the first image sequence and the second image sequence in respective areas of the substantially adjacent display areas in response to identification of the first image frame and relative to introduction of contrast agent and enables a user to synchronously increment through image frames of both the first image sequence and the second image sequence, one frame at a time.