A system to collect and analyze medical image data is applicable for multi-modality medical imaging systems, such as x-ray, MRI, and the like. Medical image data is collected and analyzed to determine one or more regions of interest. A selected region of interest is further analyzed to determine morphological characteristics. A feature library, which may be in the form of a data base, is used to analyze the image on a pixel-by-pixel basis to determine the degree to which the region of interest matches selected morphological characteristics, such as shape or margin. The resultant data is used to generate a map indicating a continuum over which the region of interest matches the morphological characteristics. A display receives the map data and applies it to the video image to thereby provide the user with a visualization of the degree to which the region of interest matches the morphological characteristics.