A radio frequency transceiver (102), including a transmitter (104), a duplexer (108) and a direct-conversion receiver (106) including a mixer (140 and 141). An IIP2 calibration system (170), coupled to the transceiver, includes an IIP2 coefficient estimator (172) for calculating an estimate of second-order distortion intermodulation distortion, and an IIP2 controller (174) for adjusting an IIP2 tuning port of the mixer in the receiver to minimize second-order distortion intermodulation distortion in the receiver that may be caused by the receiver receiving a transmit RF signal leaking through the duplexer.