A system including a processor and/or processor system can be used to identify landmarks in image data. The landmarks can be used to further identify anatomical targets. The landmarks and/or targets can be used to create a plan for a procedure, such as a surgical procedure. The processor can be used to determine the anatomical landmarks that can be used to identify anatomical targets in image data of a subject, even if the anatomical targets are indistinguishable in the image data.