A method and a device for position-dependent compliance compensation in a machine tool is disclosed. The compliance of the machine tool is derived at a position of a tool of the machine tool from machine data stored in memory, a machining force acting on the tool during a machining process at this position is determined, and at least one machining parameter that has an influence on the machining process is derived at this position in dependence on the derived compliance and the machining force so as to counteract a displacement of the tool with respect to a desired position caused by the compliance of the machine tool and the machining force. This optimizes the machining time and/or contour fidelity when machining a workpiece with a machine tool.