Invention Grant
- Patent Title: Marks as modifiers of the p53 pathway and methods of use
- Patent Title (中): 标记为p53途径的修饰剂和使用方法
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Application No.: US12802748Application Date: 2010-06-10
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Publication No.: US08153384B2Publication Date: 2012-04-10
- Inventor: Lori Friedman , Gregory D. Plowman , Helen Francis-Lang , Danxi Li , Roel P. Funke , Marcia Belvin , Mario N. Lioubin
- Applicant: Lori Friedman , Gregory D. Plowman , Helen Francis-Lang , Danxi Li , Roel P. Funke , Marcia Belvin , Mario N. Lioubin
- Applicant Address: US CA South San Francisco
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/574 ; C12Q1/00
Abstract:
Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
Public/Granted literature
- US20100325743A1 Marks as modifiers of the p53 pathway and methods of use Public/Granted day:2010-12-23
Information query
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