Invention Grant
- Patent Title: Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
- Patent Title (中): 肉毒杆菌神经毒素重组轻链和轻链融合蛋白用于研究和临床治疗
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Application No.: US12387014Application Date: 2009-04-27
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Publication No.: US08153397B2Publication Date: 2012-04-10
- Inventor: Leonard A. Smith , Melody Jensen
- Applicant: Leonard A. Smith , Melody Jensen
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Army
- Current Assignee: The United States of America as represented by the Secretary of the Army
- Current Assignee Address: US DC Washington
- Agent Elizabeth Arwine
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12P21/04 ; C12N15/09 ; C12N1/12 ; C12N1/20 ; C12N1/14 ; C12N15/00 ; C12N15/63 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The methods of the invention can provide 1.1 g of the LC per liter of culture. The LC product is stable and proteolytically active. Methods of using the products of the invention are described.
Public/Granted literature
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