Invention Grant
US08153446B2 Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems
有权
氟化合物通过光化学或化学方法转化为荧光团,并在生物系统中的应用
- Patent Title: Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems
- Patent Title (中): 氟化合物通过光化学或化学方法转化为荧光团,并在生物系统中的应用
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Application No.: US12454273Application Date: 2009-05-13
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Publication No.: US08153446B2Publication Date: 2012-04-10
- Inventor: Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
- Applicant: Robert J. Twieg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
- Applicant Address: US OH Kent US CA Palo Alto
- Assignee: Kent State University,Leland Stanford Junior University
- Current Assignee: Kent State University,Leland Stanford Junior University
- Current Assignee Address: US OH Kent US CA Palo Alto
- Agency: Hudak, Shunk & Farine Co. LPA
- Main IPC: G01N33/53
- IPC: G01N33/53

Abstract:
Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
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