Invention Grant
- Patent Title: Compositions and their uses directed to IL-4R alpha
- Patent Title (中): 组合物及其用于IL-4Rα的用途
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Application No.: US11816705Application Date: 2006-02-24
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Publication No.: US08153603B2Publication Date: 2012-04-10
- Inventor: James G. Karras , Susan Gregory , Jeffrey R. Crosby , Mausumee Guha , David Tung , Susan M. Freier
- Applicant: James G. Karras , Susan Gregory , Jeffrey R. Crosby , Mausumee Guha , David Tung , Susan M. Freier
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Jones Day
- International Application: PCT/US2006/006645 WO 20060224
- International Announcement: WO2006/091841 WO 20060831
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04
Abstract:
Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
Public/Granted literature
- US20090312398A1 COMPOSITIONS AND THEIR USES DIRECTED TO IL-4R ALPHA Public/Granted day:2009-12-17
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