Invention Grant
- Patent Title: Transcription factor decoys and use thereof
- Patent Title (中): 转录因子诱饵及其用途
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Application No.: US12626969Application Date: 2009-11-30
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Publication No.: US08153607B2Publication Date: 2012-04-10
- Inventor: Kuang-Tse Huang , Jian-En Lin
- Applicant: Kuang-Tse Huang , Jian-En Lin
- Applicant Address: TW Chiayi County
- Assignee: National Chung Cheng University
- Current Assignee: National Chung Cheng University
- Current Assignee Address: TW Chiayi County
- Agency: Frenkel & Associates, PC
- Priority: TW98128771A 20090827
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04 ; C12Q1/00
Abstract:
A pharmaceutical composition having a transcription factor decoy and a pharmaceutical acceptable carrier thereof is provided, wherein the transcription factor decoy is TCF decoy. A method for curing or preventing endotoxin-treated endothelial cells from apoptosis is provided. A method for treating or meliorating septic shock is also provided. The transcription factor decoy is effective on melioration of endothelial cell death after lipopolysaccharide challenge. Furthermore, the pharmaceutical composition is easy to be prepared, economic and has low immunogenicity.
Public/Granted literature
- US20110054010A1 Transcription Factor Decoys And Use Thereof Public/Granted day:2011-03-03
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