Invention Grant
US08153627B2 Quinazoline linked pyrrolo[2,1-C][1, 4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof
有权
喹唑啉联吡咯并[2,1-C] [1,4]苯并二氮杂杂环化合物作为潜在的抗癌剂及其制备方法
![Quinazoline linked pyrrolo[2,1-C][1, 4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof](/docs/US/2012-04-10/US08153627B2/abs.jpg.600x600.jpg)
- Patent Title: Quinazoline linked pyrrolo[2,1-C][1, 4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof
- Patent Title (中): 喹唑啉联吡咯并[2,1-C] [1,4]苯并二氮杂杂环化合物作为潜在的抗癌剂及其制备方法
-
Application No.: US12920654Application Date: 2008-10-31
-
Publication No.: US08153627B2Publication Date: 2012-04-10
- Inventor: Ahmed Kamal , Bandari Rajendra Prasad , Adla Malla Reddy
- Applicant: Ahmed Kamal , Bandari Rajendra Prasad , Adla Malla Reddy
- Applicant Address: IN New Delhi
- Assignee: Council of Scientific & Industrial Research
- Current Assignee: Council of Scientific & Industrial Research
- Current Assignee Address: IN New Delhi
- Agency: Ladas & Parry LLP
- Priority: IN518/DEL/2008 20080305
- International Application: PCT/IN2008/000712 WO 20081031
- International Announcement: WO2009/109984 WO 20090911
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/5517 ; A61P35/00
![Quinazoline linked pyrrolo[2,1-C][1, 4]benzodiazepine hybrids as potential anticancer agents and process for the preparation thereof](/abs-image/US/2012/04/10/US08153627B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides a compound of general formula 5, useful as potential antitumour agents against human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]benzodiazepine hybrids of general formula (5): wherein n=3, 4, 5, 6, 8 and wherein R1 and R2 is selected from the group consisting of R1═H, R2═H or R1═CH3O, R2=CH3O or R1═CH3O and R2═C2H5O.
Public/Granted literature
Information query
