Invention Grant
- Patent Title: Amido-tropane derivatives
- Patent Title (中): 酰胺 - 托烷衍生物
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Application No.: US13160559Application Date: 2011-06-15
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Publication No.: US08153653B2Publication Date: 2012-04-10
- Inventor: Sabine Kolczewski , Emmanuel Pinard
- Applicant: Sabine Kolczewski , Emmanuel Pinard
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP10166757 20100622
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D451/02

Abstract:
The present invention relates to a compound of formula I wherein R1, R2 and R3 are each independently hydrogen, lower alkyl, lower alkoxy, cycloalkyl, lower alkyl substituted by halogen or S-lower alkyl; or to a pharmaceutically acceptable acid addition salt, racemic mixture, or corresponding enantiomer and/or optical isomer thereof. The compounds of formula I are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors. The compounds can be used in the treatment of neurological and neuropsychiatric disorders.
Public/Granted literature
- US20110312993A1 AMIDO-TROPANE DERIVATIVES Public/Granted day:2011-12-22
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