Invention Grant
- Patent Title: Monoclonal antibodies against activated protein C
- Patent Title (中): 活化蛋白C的单克隆抗体
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Application No.: US12257706Application Date: 2008-10-24
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Publication No.: US08153766B2Publication Date: 2012-04-10
- Inventor: Jun Xu , Charles Esmon
- Applicant: Jun Xu , Charles Esmon
- Applicant Address: US OK Oklahoma City
- Assignee: Oklahoma Medical Research Foundation
- Current Assignee: Oklahoma Medical Research Foundation
- Current Assignee Address: US OK Oklahoma City
- Agency: Fulbright & Jaworski L.L.P.
- Main IPC: C07K16/24
- IPC: C07K16/24
Abstract:
The present invention provides monoclonal antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. Other antibodies inhibit both activated protein C and activation of unactivated protein C. Methods of treatment employing these antibodies are described herein as are methods of screening for and detecting these antibodies.
Public/Granted literature
- US20090110683A1 MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C Public/Granted day:2009-04-30
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