Invention Grant
US08153767B2 Antibody against aflatoxins, support using the antibody, method of immunologically detecting aflatoxins and method of concentrating and purifying aflatoxins
有权
抗黄曲霉毒素抗体,使用抗体的支持,免疫学检测黄曲霉毒素的方法和浓缩和纯化黄曲霉毒素的方法
- Patent Title: Antibody against aflatoxins, support using the antibody, method of immunologically detecting aflatoxins and method of concentrating and purifying aflatoxins
- Patent Title (中): 抗黄曲霉毒素抗体,使用抗体的支持,免疫学检测黄曲霉毒素的方法和浓缩和纯化黄曲霉毒素的方法
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Application No.: US12515263Application Date: 2007-11-13
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Publication No.: US08153767B2Publication Date: 2012-04-10
- Inventor: Mikiko Uchigashima , Shiro Miyake , Hiroshi Yamashita
- Applicant: Mikiko Uchigashima , Shiro Miyake , Hiroshi Yamashita
- Applicant Address: JP Kyoto-shi
- Assignee: HORIBA, Ltd.
- Current Assignee: HORIBA, Ltd.
- Current Assignee Address: JP Kyoto-shi
- Agency: Alleman Hall McCoy Russell & Tuttle LLP
- Priority: JP2006-311200 20061117
- International Application: PCT/JP2007/072010 WO 20071113
- International Announcement: WO2008/059837 WO 20080522
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08

Abstract:
It is intended to detect, concentrate and purify aflatoxins of all types which are possibly contained in a sample such as a food. It is also intended to detect the total amount or the individual amounts thereof at a high sensitivity. By using aflatoxin B2 or its derivative as a hapten compound, an antibody, which shows the same reactivity to individual aflatoxin analogs and is highly tolerant to organic solvents, is obtained. Then, a detection/concentration/purification means and an immunological detection means with the use of the above antibody are constructed. The detection means thus constructed achieves a high sensitivity and excellent quantification properties.
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