Invention Grant
- Patent Title: Calicheamicin derivative-carrier conjugates
- Patent Title (中): 加利车霉衍生物 - 载体缀合物
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Application No.: US10428894Application Date: 2003-05-02
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Publication No.: US08153768B2Publication Date: 2012-04-10
- Inventor: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
- Applicant: Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Paul David Robbins , Nishith Merchant , John Francis DiJoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Andrew George Popplewell
- Applicant Address: US NJ Madison
- Assignee: Wyeth Holdings Corporation
- Current Assignee: Wyeth Holdings Corporation
- Current Assignee Address: US NJ Madison
- Agency: Womble Carlyle Sandridge & Rice, LLP
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K17/00 ; C07K16/28
Abstract:
Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
Public/Granted literature
- US20040082764A1 Calicheamicin derivative-carrier conjugates Public/Granted day:2004-04-29
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