Invention Grant
- Patent Title: Methods and compositions for RNA interference
- Patent Title (中): RNA干扰的方法和组成
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Application No.: US11894676Application Date: 2007-08-20
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Publication No.: US08153776B2Publication Date: 2012-04-10
- Inventor: Gregory J. Hannon , Patrick Paddison , Emily Bernstein , Amy Caudy , Douglas Conklin , Scott Hammond
- Applicant: Gregory J. Hannon , Patrick Paddison , Emily Bernstein , Amy Caudy , Douglas Conklin , Scott Hammond
- Applicant Address: US NY Cold Spring Harbor
- Assignee: Cold Spring Harbor Laboratory
- Current Assignee: Cold Spring Harbor Laboratory
- Current Assignee Address: US NY Cold Spring Harbor
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the “target” gene).
Public/Granted literature
- US20080213861A1 Methods and compositions for RNA interference Public/Granted day:2008-09-04
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