Invention Grant
US08153777B2 Modulation of toll-like receptor 5 expression by antisense oligonucleotides
失效
通过反义寡核苷酸调节toll样受体5的表达
- Patent Title: Modulation of toll-like receptor 5 expression by antisense oligonucleotides
- Patent Title (中): 通过反义寡核苷酸调节toll样受体5的表达
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Application No.: US12612413Application Date: 2009-11-04
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Publication No.: US08153777B2Publication Date: 2012-04-10
- Inventor: Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , Sudhir Agrawal
- Applicant: Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , Sudhir Agrawal
- Applicant Address: US MA Cambridge
- Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; A61K48/00 ; A61K39/395 ; C12N15/63
Abstract:
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR5. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR5 expression and for prevention or treatment of diseases wherein modulation of TLR5 expression would be beneficial are provided.
Public/Granted literature
- US20100111937A1 Modulation of Toll-Like Receptor 5 Expression by Antisense Oligonucleotides Public/Granted day:2010-05-06
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