Invention Grant
- Patent Title: Azacytosine derivatives useful as antiviral agents
- Patent Title (中): 可用作抗病毒剂的氨基胞嘧啶衍生物
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Application No.: US12096738Application Date: 2006-12-08
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Publication No.: US08153787B2Publication Date: 2012-04-10
- Inventor: Antonin Holy , Marcela Krecmerova , Alois Piskala , Graciela Andrei , Robert Snoeck , Erik De Clercq , Johan Neyts , Lieve Naesens
- Applicant: Antonin Holy , Marcela Krecmerova , Alois Piskala , Graciela Andrei , Robert Snoeck , Erik De Clercq , Johan Neyts , Lieve Naesens
- Applicant Address: BE Leuven CZ Prague
- Assignee: K.U. Leuven Research & Development,Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic
- Current Assignee: K.U. Leuven Research & Development,Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic
- Current Assignee Address: BE Leuven CZ Prague
- Agency: Clark & Elbing LLP
- Priority: GB0525033.7 20051208; GB0526668.9 20051209; GB0611440.9 20060609
- International Application: PCT/BE2006/000130 WO 20061208
- International Announcement: WO2007/065231 WO 20070614
- Main IPC: C07F9/38
- IPC: C07F9/38 ; C07F9/40 ; C07F9/42 ; A61K31/675 ; A61P31/20 ; A61P31/22 ; C07D251/46 ; C07D251/52
Abstract:
The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmaceutical compositions comprising such 5-azacytosine derivatives as active ingredients in combination with pharmaceutically acceptable carriers, which are useful for the treatment of subjects suffering from viral infections.
Public/Granted literature
- US20090005346A1 Azacytosine Derivatives Useful as Antiviral Agents Public/Granted day:2009-01-01
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