Invention Grant
- Patent Title: Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- Patent Title (中): 11-β-羟基类固醇脱氢酶抑制剂1
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Application No.: US12297873Application Date: 2007-04-23
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Publication No.: US08153807B2Publication Date: 2012-04-10
- Inventor: Julie Kay Bush , Marvin Martin Hansen , Renhua Li , Thomas Edward Mabry , Nancy June Snyder , Owen Brendan Wallace , Yanping Xu
- Applicant: Julie Kay Bush , Marvin Martin Hansen , Renhua Li , Thomas Edward Mabry , Nancy June Snyder , Owen Brendan Wallace , Yanping Xu
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Dan L. Wood
- International Application: PCT/US2007/067182 WO 20070423
- International Announcement: WO2007/127688 WO 20071108
- Main IPC: C07D405/00
- IPC: C07D405/00 ; A61K31/535 ; A61K31/445
Abstract:
The present invention discloses novel compounds of Formula I: (I) having 11-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11-HSD type 1 activity.
Public/Granted literature
- US20090111809A1 INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 Public/Granted day:2009-04-30
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