Invention Grant
US08153820B2 Method for the production of N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides
有权
制备N-取代的(3-二卤代甲基-1-甲基吡唑-4-基)甲酰胺的方法
- Patent Title: Method for the production of N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides
- Patent Title (中): 制备N-取代的(3-二卤代甲基-1-甲基吡唑-4-基)甲酰胺的方法
-
Application No.: US12601966Application Date: 2008-05-30
-
Publication No.: US08153820B2Publication Date: 2012-04-10
- Inventor: Thomas Zierke , Joachim Rheinheimer , Michael Rack , Sebastian Peer Smidt , Ansgar Gereon Altenhoff , Joachim Schmidt-Leithoff , Nina Challand
- Applicant: Thomas Zierke , Joachim Rheinheimer , Michael Rack , Sebastian Peer Smidt , Ansgar Gereon Altenhoff , Joachim Schmidt-Leithoff , Nina Challand
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Brinks Hofer Gilson & Lione
- Priority: EP07109463 20070601
- International Application: PCT/EP2008/056712 WO 20080530
- International Announcement: WO2008/145740 WO 20081204
- Main IPC: C07D231/10
- IPC: C07D231/10

Abstract:
The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R1 is optionally substituted phenyl or C3-C7-cycloalkyl, R1a is hydrogen or fluorine, or R1a together with R1 is optionally substituted C3-C5-alkanediyl or C5-C7-cycloalkanediyl, R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C1-C4-alkoxy-C1-C2-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R1, R1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.
Public/Granted literature
- US20100174094A1 Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides Public/Granted day:2010-07-08
Information query