A shipper having an outer housing with a temperature sensitive payload and a temperature/location tracker disposed therein. The outer housing has a body having an interior surface bounding a compartment that is accessed through an opening. A first panel is coupled with the body and configured to extend over at least a portion of the opening, with a first access port extending through the first panel. The payload and temperature/location tracker are disposed within the compartment of the body. The temperature/location tracker includes a first temperature probe, a GPS receiver, a cellular modem, and a GPS antenna. The GPS antenna is disposed so as to be aligned with the first access port when the shipper is in a fully assembled state such that the GPS antenna is directly accessible through the first access port. The temperature/location tracker monitors and periodically transmits temperature and location values of the shipper over a cellular communication network.