Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation

Invention Grant

US08163551B2 Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation 有权

Title translation: 用于制备具有降低核心岩藻糖基化的抗体和抗体衍生物的方法和组合物

Patent Title: Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
Patent Title (中): 用于制备具有降低核心岩藻糖基化的抗体和抗体衍生物的方法和组合物
Application No.: US12434533

Application Date: 2009-05-01
Publication No.: US08163551B2

Publication Date: 2012-04-24
Inventor: Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
Applicant: Stephen C. Alley , Scott C. Jeffrey , Django Sussman , Dennis R. Benjamin , Brian Toki , Patrick J. Burke
Applicant Address: US WA Bothell
Assignee: Seattle Genetics, Inc.
Current Assignee: Seattle Genetics, Inc.
Current Assignee Address: US WA Bothell
Agency: Kilpatrick Townsend & Stockton LLP
Main IPC: C12N5/06
IPC: C12N5/06 ; C12N5/00 ; C07K16/00

Abstract:

The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.

Abstract(Chinese):

本发明提供了制备具有降低核心岩藻糖基化的抗体和抗体衍生物的方法和组合物。

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