The invention relates to a method of computing a disparity, a method of synthesizing an interpolation view, a method of encoding and decoding multi-view video using the same, and an encoder and a decoder using the same. In particular, the invention relates to a method of computing a disparity, a method of synthesizing an interpolation view, a method of encoding and decoding multi-view video using the same, and an encoder and a decoder using the same, which can rapidly compute an initial disparity of a block using region segmentation, accurately compute a disparity of the block using a variable block, and synthesize an interpolation view on the basis of a disparity value computed in a pixel basis using an adaptive search range, thereby improving quality of the interpolation view, and also can encode and decode a multi-view video independently from an existing prediction mode while using the interpolation view as a reference picture, thereby improving coding efficiency.