A cooling and warming blanket includes a blanket, a first channel, and a plurality of air chambers. The blanket includes an upper layer and a lower layer, each of which further includes a cover layer and an inner layer. The inner layers of the upper and lower layers are melted and integrated into one piece by high-frequency sealing to define a liquid inputting area and a liquid outputting area. The first channel is formed between a portion of the liquid inputting and outputting areas for conveying a liquid from the liquid inputting area to the liquid outputting area. The air chambers are formed in the liquid inputting and outputting areas, and a second channel is formed between each two adjacent air chambers. Thus, the liquid in the liquid inputting and outputting areas can be conveyed throughout the liquid inputting and outputting areas via the second channels.