Invention Grant
US08168174B2 Method of isolating human neuroepithelial precursor cells from human fetal tissue
有权
从人胎儿组织中分离人神经上皮前体细胞的方法
- Patent Title: Method of isolating human neuroepithelial precursor cells from human fetal tissue
- Patent Title (中): 从人胎儿组织中分离人神经上皮前体细胞的方法
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Application No.: US12395677Application Date: 2009-03-01
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Publication No.: US08168174B2Publication Date: 2012-05-01
- Inventor: Margot Mayer-Proschel , Mahendra S. Rao , Patrick A. Tresco , Darin J. Messina
- Applicant: Margot Mayer-Proschel , Mahendra S. Rao , Patrick A. Tresco , Darin J. Messina
- Applicant Address: US UT Salt Lake City
- Assignee: University of Utah Research Foundation
- Current Assignee: University of Utah Research Foundation
- Current Assignee Address: US UT Salt Lake City
- Agency: Licata & Tyrrell P.C.
- Main IPC: C12N5/0797
- IPC: C12N5/0797 ; A61K35/30
Abstract:
A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
Public/Granted literature
- US20090162330A1 Method of Isolating Human Neuroepithelial Precursor Cells from Human Fetal Tissue Public/Granted day:2009-06-25
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