Invention Grant
US08168194B2 Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes
有权
包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和人免疫缺陷病毒（HIV）Tat支架多肽的融合蛋白
- Patent Title: Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes
- Patent Title (中): 包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和人免疫缺陷病毒（HIV）Tat支架多肽的融合蛋白
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Application No.: US11883696Application Date: 2006-02-03
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Publication No.: US08168194B2Publication Date: 2012-05-01
- Inventor: Susan Barnett , Rino Rappuoli , Victoria A. Sharma , Indresh K. Srivastava , Jan Zur Megede
- Applicant: Susan Barnett , Rino Rappuoli , Victoria A. Sharma , Indresh K. Srivastava , Jan Zur Megede
- Applicant Address: US CA Emeryville
- Assignee: Novartis Vaccines & Diagnostics, Inc.
- Current Assignee: Novartis Vaccines & Diagnostics, Inc.
- Current Assignee Address: US CA Emeryville
- Agent Regina Bautista; Helen Lee
- International Application: PCT/US2006/003935 WO 20060203
- International Announcement: WO2006/084179 WO 20060810
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/21 ; A61K38/00 ; C07K1/00
Abstract:
Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
Public/Granted literature
- US20080317779A1 Hiv Tat-Cd4 Hybrid Molecules and Methods of Use Thereof Public/Granted day:2008-12-25
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