Invention Grant
- Patent Title: Method to modulate hematopoietic stem cell growth
- Patent Title (中): 调节造血干细胞生长的方法
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Application No.: US12294344Application Date: 2007-04-26
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Publication No.: US08168428B2Publication Date: 2012-05-01
- Inventor: Leonard I. Zon , Trista E. North , Wolfram Goessling
- Applicant: Leonard I. Zon , Trista E. North , Wolfram Goessling
- Applicant Address: US MA Boston US MA Boston
- Assignee: Children's Medical Center Corporation,The General Hospital Corporation
- Current Assignee: Children's Medical Center Corporation,The General Hospital Corporation
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick
- International Application: PCT/US2007/007419 WO 20070426
- International Announcement: WO2007/112084 WO 20071004
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02
Abstract:
The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Public/Granted literature
- US20090285786A1 METHOD TO MODULATE HEMATOPOIETIC STEM CELL GROWTH Public/Granted day:2009-11-19
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