Invention Grant
US08168588B2 Compositions comprising FGF-9 and betacellulin and methods for treating cardiac conditions
有权
包含FGF-9和β细胞素的组合物和治疗心脏病症的方法
- Patent Title: Compositions comprising FGF-9 and betacellulin and methods for treating cardiac conditions
- Patent Title (中): 包含FGF-9和β细胞素的组合物和治疗心脏病症的方法
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Application No.: US11795915Application Date: 2006-01-25
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Publication No.: US08168588B2Publication Date: 2012-05-01
- Inventor: Lewis T. Williams , Hongbing Zhang , Yan Wang , Loriane Masuoka , Stephen Doberstein
- Applicant: Lewis T. Williams , Hongbing Zhang , Yan Wang , Loriane Masuoka , Stephen Doberstein
- Applicant Address: US CA South San Francisco
- Assignee: Five Prime Therapeutics, Inc.
- Current Assignee: Five Prime Therapeutics, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- International Application: PCT/US2006/002313 WO 20060125
- International Announcement: WO2006/081190 WO 20060803
- Main IPC: A61K38/18
- IPC: A61K38/18 ; A61K38/00 ; A61K39/00
Abstract:
Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby treating cardiac conditions. Methods of providing these compositions to the cardiac area include catheterization and direct injection. In preferred embodiments, the compositions comprise one of more of the following growth factors: EGF, bFGF, cardiotrophin-1, thrombin, PDGF-BB, amphiregulin, epiregulin, HB-EGF, TGFalpha, betacellulin, heregulin alpha, NRG-1-beta1-HRG-beta1, FGF 9.
Public/Granted literature
- US20090018061A1 Compositions and Methods for Treating Cardiac Conditions Public/Granted day:2009-01-15
Information query
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