Invention Grant
- Patent Title: Use of proteolysis resistant active VEGF
- Patent Title (中): 使用蛋白水解抗性活性VEGF
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Application No.: US12349531Application Date: 2009-01-07
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Publication No.: US08168590B2Publication Date: 2012-05-01
- Inventor: Sabine Eming , Thomas Krieg , Stephan Sollberg , Gereon Lauer
- Applicant: Sabine Eming , Thomas Krieg , Stephan Sollberg , Gereon Lauer
- Applicant Address: DE Duesseldorf
- Assignee: Bayer Innovation GmbH
- Current Assignee: Bayer Innovation GmbH
- Current Assignee Address: DE Duesseldorf
- Agency: Pequignot + Myers LLC
- Agent Joyce Von Natzmer
- Priority: EP02005186 20020308
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/475
Abstract:
The invention relates to vascular endothelial growth factor (VEGF) in which the alanine at AA position 111 is replaced by proline. The arginine at AA position 110 may moreover be replaced by another amino acid. The invention also relates to derivatives of the VEGF according to the invention, nucleic acids, expression systems, medicaments and the use of the VEGF mutants of the invention for the treatment of chronic wounds.
Public/Granted literature
- US20110009316A1 PROTEOLYSIS RESISTANT ACTIVE VEGF Public/Granted day:2011-01-13
Information query
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