Invention Grant
US08168593B2 Mutated netrin-4, fragments thereof and their use as medicines
失效
突变的netrin-4，其片段及其作为药物的用途
- Patent Title: Mutated netrin-4, fragments thereof and their use as medicines
- Patent Title (中): 突变的netrin-4，其片段及其作为药物的用途
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Application No.: US13171756Application Date: 2011-06-29
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Publication No.: US08168593B2Publication Date: 2012-05-01
- Inventor: Jean Plouet , Monica Alemany
- Applicant: Jean Plouet , Monica Alemany
- Applicant Address: FR Paris FR Paris
- Assignee: Centre National de la Recherche Scientifique,IVS Institut des Vaisseaux et du Sang
- Current Assignee: Centre National de la Recherche Scientifique,IVS Institut des Vaisseaux et du Sang
- Current Assignee Address: FR Paris FR Paris
- Agency: Young & Thompson
- Priority: FR0412362 20041122; FR0412364 20041122
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; C12N15/00 ; A01N61/00 ; A61K38/00 ; C07K1/00 ; C07K14/00 ; C07K17/00 ; C07H1/00 ; C07H5/04 ; C07H5/06 ; C07H21/04
Abstract:
A peptide fragment of the netrin-4 protein and nucleic acids coding for the peptide are described. The peptide can inhibit endothelial cell proliferation and cell migration, as well as activate the proliferation and migration of pericytes and smooth muscle cells. Pharmaceutical formulations containing the peptide and/or the nucleic acids can be used to treat a variety of tumoral and non-tumoral pathologies.
Public/Granted literature
- US20110280876A1 MUTATED NETRIN - 4, FRAGMENTS THEREOF AND THEIR USE AS MEDICINES Public/Granted day:2011-11-17
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