Invention Grant
- Patent Title: Method of delivering RNA interference and uses thereof
- Patent Title (中): 递送RNA干扰的方法及其用途
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Application No.: US11659386Application Date: 2005-08-15
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Publication No.: US08168601B2Publication Date: 2012-05-01
- Inventor: Judy Lieberman , Erwei Song
- Applicant: Judy Lieberman , Erwei Song
- Applicant Address: US MA Boston
- Assignee: Immune Disease Institute, Inc.
- Current Assignee: Immune Disease Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- International Application: PCT/US2005/029111 WO 20050815
- International Announcement: WO2006/023491 WO 20060302
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04 ; C07K16/00
Abstract:
The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically binds to a site on a target cell, and (2) a binding moiety, which will bind to the double stranded RNA, wherein the double stranded RNA segment initiates RNA interference in the cell.
Public/Granted literature
- US20080153737A1 Method of Delivering Rna Interference and Uses Thereof Public/Granted day:2008-06-26
Information query
